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Anastasiadou, E., Seto, A. G., Beatty, X., Hermreck, M., Gilles, M. E., Stroopinsky, D., Pinter-Brown, L. C., Pestano, L., Marchese, C., Avigan, D., Trivedi, P., Escolar, D. M., Jackson, A. L., & Slack, F. J. (2021). Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clinical cancer research : an official journalContinue reading

Zhang, W.C., Wells, J.M., Chow, K. et al. miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Nat Metab 1, 460–474 (2019). https://doi.org/10.1038/s42255-019-0052-9 Abstract: Drug tolerance is an acute defence response preceding a fully drug-resistant state and tumour relapse; however, there are few therapeutic agents targeting drug tolerance inContinue reading

Multi-layered control of PD-L1 expression in Epstein-Barr virus-associated gastric cancer.

Miliotis CN, Slack FJ. Multi-layered control of PD-L1 expression in Epstein-Barr virus-associated gastric cancer. J Cancer Metastasis Treat 2020;6:13. http://dx.doi.org/10.20517/2394-4722.2020.12 Abstract: Gastric cancer (GC) is the fifth most common cancer worldwide. In approximately 10% of GC cases, cancer cells show ubiquitous and monoclonal Epstein-Barr virus (EBV) infection. A significant feature of EBV-associated GC (EBVaGC) is high lymphocytic infiltration and highContinue reading “Multi-layered control of PD-L1 expression in Epstein-Barr virus-associated gastric cancer.”