Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

Lee, J. D., Menasche, B. L., Mavrikaki, M., Uyemura, M. M., Hong, S. M., Kozlova, N., Wei, J., Alfajaro, M. M., Filler, R. B., Müller, A., Saxena, T., Posey, R. R., Cheung, P., Muranen, T., Heng, Y. J., Paulo, J. A., Wilen, C. B., & Slack, F. J. (2023). Differences in syncytia formation by SARS-CoV-2

Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5

Li, C., Yoon, B., Stefani, G., & Slack, F. J. (2023). Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5. Nucleic acids research, 51(18), 9849–9862. https://doi.org/10.1093/nar/gkad709 Abstract: MicroRNAs (miRNAs) are small non-coding RNAs first discovered in Caenorhabditis elegans. The let-7 miRNA is highly conserved in sequence, biogenesis and function from

Severe COVID-19 is associated with molecular signatures of aging in the human brain

Mavrikaki, M., Lee, J. D., Solomon, I. H., & Slack, F. J. (2022). Severe COVID-19 is associated with molecular signatures of aging in the human brain. Nature aging, 2(12), 1130–1137. https://doi.org/10.1038/s43587-022-00321-w Abstract: As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar

The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2

Matai, L., Stathis, T., Lee, J. D., Parsons, C., Saxena, T., Shlomchik, K., & Slack, F. J. (2023). The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2. Aging cell, 22(4), e13785. https://doi.org/10.1111/acel.13785 Abstract: Several microRNAs have emerged as regulators of pathways that control aging. For example, miR-228 is